More to Cinryze Than Meets the Eye

13 Jan

I received my second shipment of Cinryze today and I have more information and tips to share.

Unlike my first shipment, where the prescription label on the plastic bag encasing each dose (two vials in individual manufacturer’s boxes) of Cinryze read, “Store at Room Temperature,” this shipment arrived in a cardboard box with an “Immediately Refrigerate” sticker prominently displayed on the outside, but no storage instructions at all on the prescription label on the plastic bag encasing each dose.

Since I needed to discuss some supply issues with TheraCom anyway, I asked my Nursing Case Manager about her official stance on the subject of refrigeration. She agreed that “Store at Room Temperature” was ambiguous at best and that the Prescribing Information (see cinryze-prescribing-information-1) is technically correct: store between 36oF-77oF and do not freeze. Most refrigerators fit comfortably within this temperature range.

Now, most women out there going through peri-menopause or menopause with tell you, in no uncertain terms, the temperature of their homes are never higher than 68oF, no matter the time of year (that’s me over there, jumping up and down, raising my hand). As long as Cinryze is kept in its original manufacturer’s box (i.e., away from light), a house with a room temperature of 68oF makes a fine refrigerator and is safely within range.


Your specialty pharmacy technician should call you before your shipment leaves their facility to confirm exactly which and how much supplies you need to administer your Cinryze. No matter how you administer, several kinds of supplies will be needed. When your shipment arrives, I highly recommend you sort them into kits using ziploc/plastic bags (or your favorite storage medium). If you do this upon receipt, you will (1) immediately know if you received everything you need and (2) have all the correct supplies in one place each time you need to infuse.

Since I have a portacath, I create two kits: The first I use in conjunction with one of the second (and then leave my port accessed for one month), and the second I use alone each time I administer Cinryze between port access:

Kit to Access Port:

  1. Sterile Drape (one)
  2. Sterile Gloves (one set)
  3. Transparent Dressing (Tegaderm) (one)
  4. Chloraprep or Betadine Swabsticks or Applicators (one set of 3)
  5. Alcohol Pad (one)
  6. Micro-Clave (one)
  7. Biopatch (one)
  8. Huber Needle with attached IV Line (one)
  9. Protective Skin Prep (one)

Note: Items 1 through 5 may be provided separately (as listed) or combined for you in a Central Line Change Dressing Kit

Kit to Administer Cinryze Through Port:

  1. Cinryze (two vials)
  2. Sterile Water (two vials)
  3. Pre-Filled Saline Flushes (two)*
  4. Pre-Filled Heparin Flush (one)*
  5. Mix2Vial (two)
  6. 10cc Syringe (one)
  7. Alcohol Pad (two)

If you don’t have a portacath, your single kit might consist of the following items:

Kit to Administer Cinryze w/o Port:

  1. Cinryze (two vials)
  2. Sterile Water (two vials)
  3. Pre-Filled Saline Flushes (two)
  4. Pre-Filled Heparin Flush (one)
  5. Syringe (one)
  6. Mix2Vial (two)
  7. Sterile Gloves (one set)
  8. Butterfly Safety Needle with attached IV Line (one)
  9. Alcohol Pad (two)

As you can see, there are quite a few pieces of the puzzle required to “pull off” an infusion, and trying to pull together 23, 12 or 14 items to do a “rescue” infusion could be life threateningly slow. Organization could save your, or your loved one’s, life.

*Needed to complete port access; however, I always do an infusion immediately following port access and combine this kit with the port access kit.

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